Protocol considerations for multigenerational blinding of preimplantation genetic testing for a monogenic condition for Huntington disease: a case report
Multigenerational blinding of PGT-M for trinucleotide repeat disorders has great utility in preserving patient autonomy while limiting the risk of future progeny inheriting a life-limiting genetic condition. Careful, comprehensive counseling and multilevel strategies should be developed to enact these blinding measures to best serve patients and their families whose genetic information is being used for testing.
Authors
- Dana R. Siegel (ORCID: https://orcid.org/0000-0001-9556-1609)
- Ana Cerveró
- José Antonio Martínez-Conejero
- Samuel Raine (ORCID: https://orcid.org/0000-0003-4828-0972)
- Paulina Nassab
- Alex J. Polotsky (ORCID: https://orcid.org/0000-0003-3131-2499)
- Liya Rabkina
- Hannah Elfman
Institutions
- University Memory and Aging Center (US)
- Igenomix (ES)
- Shady Grove Fertility Center (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- F&S Reports
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.xfre.2025.03.007
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91