Local skin reaction tointramuscular administrationof enrofloxacin in pythons

Two cases of local skin reactions to intramuscular application of enrofloxacin in a reticulatedpython (Malayopython reticulatus) (6 years, 5.5 kg) and a Burmese python (Python bivitatus) (3 years, 25 kg) are presented. The reticulated python was treated for a swelling of the upper jaw, while the Burmese python had respiratory symptoms. The first python was treated with meloxicam for 7 days, but since the swelling did not go down, the local veterinarian consulted a reptile expert. Instead of the recommended marbofloxacin, the animal received an intramuscular injection of enrofloxacin, and swelling and a sterile abscess appeared at the injection site, with local pinkish skin discolouration. After marbofloxacin therapy was continued, the swelling disappeared. The white spotpatch at the site of the single application of enrofloxacin is still present after3 months. The Burmese python received enrofloxacin and bromhexine hydrochloride intramuscularly for 14 days. Sterile abscesses and skin discolouration occurred at 3-4 sites of enrofloxacin application. Initially, the scales around the site of enrofloxacin application became pale and matte, later appearing as though the scales had melted or fused. Even 5 years later, a slight spherical bulge with a hard-elastic consistency can be felt. The treatment was carried out in another local clinic.Intramuscular application of enrofloxacin in pythons can lead to the formation of a sterile abscess at the injection site and long-term discolouration of the skin above that site, although some prescriptions warn of possible skin discoloration, but only after subcutaneous administration of enrofloxacin.