cGAS and STING in Host Myeloid Cells Are Essential for Effective Cyclophosphamide Treatment of Advanced Breast Cancer
Our study demonstrates that the CD8<sup>+</sup>-T-cell-dependent anti-tumor mechanisms of CTX critically involve the cGAS-STING-IFN-I axis, IFN-I response, and STING-independent cGAS function in host myeloid cells. These findings suggest the deployment of CTX in treating advanced solid tumor to bypass the often-failed IFN-I production by tumor cells due to the chronic activation of intrinsic cGAS-STING caused by chromosomal instability.
Authors
- Yae-Huei Liou (ORCID: https://orcid.org/0000-0001-6758-7318)
- Yung‐Hsiang Chen (ORCID: https://orcid.org/0000-0002-8756-5113)
- Hao-Ting Liao (ORCID: https://orcid.org/0009-0008-9048-7698)
- Nan‐Shih Liao (ORCID: https://orcid.org/0000-0003-3707-4145)
- Zhenqi Wu (ORCID: https://orcid.org/0000-0001-9152-0463)
- Yein‐Gei Lai (ORCID: https://orcid.org/0000-0002-7342-4395)
- Shih‐Wen Huang
Institutions
- National Central University (TW)
- Institute of Molecular Biology, Academia Sinica (TW)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3390/cancers17071130
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Academia Sinica