Construction of C4-Spirocyclic Chiral Covalent Organic Frameworks Via Asymmetric Multicomponent Povarov Reaction for Enantioselective Sensing
Although many chiral covalent organic frameworks (CCOFs) have been synthesized, the rapid development of this field has been severely restricted by the limitations of CCOFs synthesis methods and the scarcity of their chiral structural unit types. Herein we report, for the first time, the construction of C4-spirocyclic CCOFs via the asymmetric multicomponent Povarov reaction under ambient conditions. The obtained <b>C4</b>-<b>spiro</b>-(2<i>S</i>, 4<i>R</i>)-<b>TMTT</b>-<b>COF</b> can be as a novel chiral fluorescent sensor to discriminate D/L-PAL enantiomers. This finding will provide a simple and universal method for constructing CCOFs with novel chiral structural groups and might open new insights into the construction of the CCOFs featuring multiple distinct types of carbon chiral centers.
Authors
- Yu‐Bin Dong (ORCID: https://orcid.org/0000-0002-9698-8863)
- Ziran Liu (ORCID: https://orcid.org/0000-0002-8980-7374)
- Jing‐Lan Kan (ORCID: https://orcid.org/0000-0003-2874-9139)
- Jian‐Cheng Wang (ORCID: https://orcid.org/0000-0001-5325-4432)
- Wenting Yang
- Zhi Chen (ORCID: https://orcid.org/0000-0001-9173-754X)
- Wenyan Li (ORCID: https://orcid.org/0000-0003-1861-6383)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-8861-7336)
- Jianzhong Fan (ORCID: https://orcid.org/0000-0003-2176-2621)
Institutions
- Academy of Medical Sciences (GB)
- Shandong Normal University (CN)
- Ministry of Education (ME)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1021/jacs.4c18474
- Citations
- 11
- Primary Topic
- Covalent Organic Framework Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.70
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Taishan Scholar Project of Shandong Province
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China