Mechanism of non-coding RNA regulation of DNMT3A
Our results are consistent with a model for RNA regulation of DNMT3A that involves localized production of short RNAs binding to a nonspecific site on the protein, rather than formation of localized RNA/DNA structures. We propose that regulatory RNAs play a dominant role in the regulation of DNMT3A catalytic activity at sites with increased production of regulatory RNAs.
Authors
- Aaron J. Salisbury
- Jonathan E. Sandoval (ORCID: https://orcid.org/0000-0003-1986-0804)
- Nancy V. N. Carullo (ORCID: https://orcid.org/0000-0001-9197-5046)
- Norbert O. Reich (ORCID: https://orcid.org/0000-0001-6032-2704)
- Jeremy J. Day (ORCID: https://orcid.org/0000-0002-7361-3399)
Institutions
- University of California, Santa Barbara (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s13072-025-00574-w
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation