Assessment of Relative Contributions of Lifestyle, Behavioral and Biological Risk Factors for Cervical Human Papillomavirus Infections in Female Sex Workers
This study aimed to identify and quantify the relative and collective contributions of lifestyle, behavioral, and biological risk factors to cervical HPV infections among female sex workers (FSWs) in Ibadan, Nigeria. This cross-sectional study was part of the Sexual Behavior and HPV Infections in Nigerians in Ibadan project and involved 182 FSWs for whom complete data on HPV genotypes were available. Quantile-based g-computation was employed to assess the relative and collective contributions of risk factors to any cervical HPV/hrHPV infections and multiple cervical HPV/hrHPV. The collective contribution of all selected risk factors to multiple high-risk cervical HPV was 2.47 (95% CI: 0.97-3.23). The number of other anatomic sites with HPV infections showed the highest positive relative contribution to multiple cervical HPV/hrHPV. Alcohol consumption and the total number of sexual partners contributed to high-risk cervical HPV and multiple cervical HPV/hrHPV, while age at first vaginal sex had a negative relative contribution. This study highlights the significant contribution of HPV infections in multiple anatomic sites as a risk to the acquisition of cervical HPV in FSWs. Routine screening protocols should be enhanced to include multiple anatomic sites, and targeted educational programs are recommended to address the specific risks faced by FSWs.
Authors
- Mamoudou Maïga (ORCID: https://orcid.org/0000-0001-7871-3973)
- Lifang Hou (ORCID: https://orcid.org/0000-0003-4877-0031)
- Elizabeth Christian (ORCID: https://orcid.org/0000-0002-7068-7843)
- Yinan Zheng (ORCID: https://orcid.org/0000-0002-2006-7320)
- Jonah Musa (ORCID: https://orcid.org/0000-0002-7836-0976)
- Deborah Watson‐Jones (ORCID: https://orcid.org/0000-0001-6247-1746)
- Miguel Ángel Pavón (ORCID: https://orcid.org/0000-0003-3677-5329)
- Suzanna C. Francis (ORCID: https://orcid.org/0000-0002-3724-4813)
- Kyeezu Kim (ORCID: https://orcid.org/0000-0002-9094-9011)
- Imran Oludare Morhason-Bello (ORCID: https://orcid.org/0000-0002-7448-4824)
- Isaac F. Adewole (ORCID: https://orcid.org/0000-0002-5341-2514)
- Sunday O. Oyerinde
- Oluwasegun Caleb Idowu
- Yusuf Bello (ORCID: https://orcid.org/0000-0003-3284-3232)
- Adeola Fowotade (ORCID: https://orcid.org/0000-0002-0224-7600)
- Olufemi J. Ogunbiyi (ORCID: https://orcid.org/0000-0002-8748-2879)
- Jun Wang (ORCID: https://orcid.org/0000-0002-2678-2456)
- Kathy Baisley
Institutions
- Northwestern University (US)
- University of London (GB)
- University of Jos (NG)
- University of Ibadan (NG)
- University College Hospital, Ibadan (NG)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- London School of Hygiene & Tropical Medicine (GB)
- Mwanza Intervention Trials Unit (TZ)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- National Institute for Medical Research (TZ)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Viruses
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3390/v17040485
- Citations
- 3
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- University of Ibadan