Phenotype-Based Classification of Obstructive Hypertrophic Cardiomyopathy Undergoing Myectomy
This study partitioned variables derived from clinical and pathological information in patients who received septal reduction therapy to identify obstructive hypertrophic cardiomyopathy subtypes. Subtype 1 was characterized by a high percentage of sarcomere mutation carriers and the highest interventricular septal thickness. Subtype 2 was featured by left atrial enlargement and a high percentage of patients with atrial fibrillation. Subtype 3 was characterized by a high left ventricular outflow tract gradient, serious inflammatory cell infiltration, and a high incidence of postoperative adverse events. This finding has been well replicated in 2 validation cohorts with short- and long-term follow-up.
Authors
- Xiumeng Hua (ORCID: https://orcid.org/0009-0006-5424-8812)
- Hao Nie (ORCID: https://orcid.org/0000-0002-8985-1279)
- Congrui Wang (ORCID: https://orcid.org/0000-0002-7997-1381)
- Qian Zhao (ORCID: https://orcid.org/0000-0001-6555-4467)
- Jiangping Song
- Mengxia Fu (ORCID: https://orcid.org/0000-0002-6286-9233)
- Hao Cui (ORCID: https://orcid.org/0000-0001-7634-748X)
- Wendao Liu (ORCID: https://orcid.org/0000-0002-5124-9338)
- Songren Shu (ORCID: https://orcid.org/0000-0001-8659-197X)
- Hao Jia (ORCID: https://orcid.org/0000-0002-4736-0957)
- Ningning Zhang (ORCID: https://orcid.org/0000-0001-6744-3867)
- Yunhu Song
- Xiao Cheng (ORCID: https://orcid.org/0000-0003-3372-4008)
- Yifan Wang (ORCID: https://orcid.org/0009-0003-9385-5277)
- Siyuan Huang
- Yuan Chang (ORCID: https://orcid.org/0009-0008-2239-7383)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Fu Wai Hospital (CN)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.jacbts.2024.12.016
- Citations
- 3
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.16