One Pot Synthesis and antibacterial activity of 4-phenyl-2-thioxo-1, 2, 3, 4-Tetrahydropyrimidine-5-Carboxylate analogous catalysed by Mg (NO3)2 as Catalyst

In the present study, the main focus for synthesis of to find a molecule bearing containing drug treatment means the drug which resists the antimicrobial activities scaffold due to microbial infection and study of the exploration of chemistry and medicinal diversity of pyrimidine-2-thiones. An efficient three component one pot synthesis of Methyl-6-methyl-4-phenyl -2-thioxo-1, 2, 3, 4-tetrahydro pyrimidineidin-5-yl) ethanone based on the reaction of readily available of starting molecules aromatic aldehyde, acetyl acetone and thiourea in presence followed by Mg (NO3)2 as a catalysed dehydration as well as solvent The products were prepared in good excellent yield under mild, solvent as well as catalysed conditions. The structure of these derivatives has been calculated on the basis of their advanced spectroscopic data 1HNMR, 13CNMR and LCMS spectral data and also structural determination was estimated by elemental analysis. KEY WORDS: Aacetyl acetone, aromatic aldehyde, thiourea, Mg (NO3)2, tetrahydropyrimidine-5-carboxylate, antimicrobial activities