The role of caffeine-synthesized silver nanoparticles in mitigating radiation-induced liver damage in Swiss albino mice: A histopathological study

This study investigates the potential protective effects of caffeine-synthesized silver nanoparticles (AgNPs) on liver damage induced by ionizing radiation in Swiss Albino mice. The liver, a vital organ for detoxification and metabolism, is highly susceptible to radiation-induced injury, which manifests as cellular necrosis, inflammation, and fibrosis. The synthesis of silver nanoparticles using caffeine, a natural antioxidant and radioprotective agent, aims to harness the dual benefits of caffeine's protective properties and the nanoparticle's potential for cellular repair. In this study, Swiss Albino mice were exposed to gamma radiation, followed by administration of caffeine-synthesized silver nanoparticles. Histopathological examination of liver tissues revealed the extent of protection provided by these nanoparticles, as compared to the untreated control group. The results suggest that caffeine-synthesized AgNPs exhibit significant radioprotective effects by reducing liver damage, promoting tissue regeneration, and mitigating oxidative stress.