Unveiling a novel in-vitro model of skin inflammaging
A novel <i>in-vitro</i> model of sensitive skin inflammaging was developed by applying the supernatant of the M1 macrophage culture medium to induce cellular senescence in fibroblast cells, facilitating the screening of anti-inflammaging ingredients. In this model, supramolecular bakuchiol could promote collagen COL1A1 and COL3A3 production and inhibit inflammatory factors by enhancing the transcription of anti-inflammatory genes (<i>PTX3, ADAM33</i>, and <i>PDLIM1</i>), while <i>Terminalia chebula</i> extract inhibits cell senescence by reducing the transcription of MAP4K2 and the accumulation of the inflammatory factor CCL3.
Authors
- Linlin Xu (ORCID: https://orcid.org/0000-0002-2473-2981)
- Ying Xu (ORCID: https://orcid.org/0000-0002-0656-9738)
- Yue Liu (ORCID: https://orcid.org/0009-0004-8003-8814)
- Yao Li (ORCID: https://orcid.org/0009-0007-2980-5274)
- Jun‐Xiang Li
- Kun Dong (ORCID: https://orcid.org/0000-0001-7006-274X)
- Tao Zhang (ORCID: https://orcid.org/0000-0001-9725-0185)
- Xiao Lin (ORCID: https://orcid.org/0009-0009-8940-598X)
Institutions
- Northwestern Polytechnical University (CN)
- Beijing Technology and Business University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3389/fmed.2025.1556680
- Citations
- 2
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.01