High-Fat Diet in Perinatal Period Promotes Liver Steatosis and Low Desaturation Capacity of Polyunsaturated Fatty Acids in Dams: A Link with Anxiety-Like Behavior in Rats
These findings suggest that long-term HFD consumption alters tissue fatty acid composition, disrupts metabolic homeostasis, and contributes to behavioral changes, increasing anxiety-like behaviors in pregnant dams and reducing social interactions in male offspring. Overall, this study provides further insight into the detrimental effects of HFD consumption during the perinatal period.
Authors
- Lorena Mercado (ORCID: https://orcid.org/0009-0007-9813-8815)
- Yasna Muñoz (ORCID: https://orcid.org/0000-0003-3554-7543)
- Alejandra Espinosa (ORCID: https://orcid.org/0000-0003-4779-5341)
- Alexies Dagnino‐Subiabre (ORCID: https://orcid.org/0000-0002-9909-9826)
- María Paz Beyer (ORCID: https://orcid.org/0009-0003-3075-5383)
- Rodrigo Valenzuela (ORCID: https://orcid.org/0000-0001-9298-6142)
- Camila Farías (ORCID: https://orcid.org/0000-0003-4899-9709)
- Angie V. Caicedo-Paz
- Robinson Carrasco-Gutiérrez (ORCID: https://orcid.org/0009-0006-6844-956X)
Institutions
- Pontificia Universidad Católica de Valparaíso (CL)
- Universidad Andrés Bello (CL)
- University of Chile (CL)
- University of Valparaíso (CL)
Publication Details
- Journal
- Nutrients
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3390/nu17071180
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Agencia Nacional de Investigación y Desarrollo