One‐Pot Three‐Component Coupling Access to Indolizine‐Pyrrolodiazepine Hybrid Structures
Abstract A highly efficient assembly of a new indolizine‐pyrrolodiazepine hybrid skeleton was achieved from one‐pot three‐component coupling of pyridine‐2‐acetonitrile, N ‐substituted pyrrole‐2‐carboxaldehyde, and TMSCN in the presence of DBU through a domino aldol condensation‐Michael addition‐cycloisomerization‐imine formation sequence which allowed for consecutive construction of two central rings (pyrrole and diazepine) of the tetracyclic product with formation of two C─C and two C─N bonds.
Authors
- Ikyon Kim (ORCID: https://orcid.org/0000-0002-0849-5517)
- Seonghyeon Nam (ORCID: https://orcid.org/0000-0003-1266-3568)
- Sun Hee Lee (ORCID: https://orcid.org/0000-0002-6045-0295)
Institutions
- Yonsei University (KR)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1002/ajoc.202500100
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00