Suppression of BRCA1 facilitates kidney regeneration
Maladaptive repair following kidney injury leads to the development of kidney disease. In this issue of JEM, Ajay et al. (https://doi.org/10.1084/jem.20231107) uncover the role of breast cancer susceptibility gene 1 (BRCA1) in cell cycle arrest, DNA damage, and cell senescence, preventing maladaptive repair.
Authors
- Raghu Kalluri (ORCID: https://orcid.org/0000-0002-2190-547X)
- Kaira A. Church (ORCID: https://orcid.org/0000-0002-3982-8476)
- Xunian Zhou (ORCID: https://orcid.org/0000-0002-3287-8913)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- University of Houston (US)
- Rice University (US)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1084/jem.20241814
- Citations
- 1
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.81