Categorizing Concentration Confidence: A Framework for Reporting Concentration Measures from Mass Spectrometry-Based Assays
We propose a simple scheme to report concentrations for targeted and untargeted analytes. Level 1 is a confirmed concentration following established tolerances in a fully quantitative assay while level 5 is a tentative intensity from a typical untargeted assay. This framework enables easy communication of uncertainty in concentration measurements to aid cross-validation, meta-analysis, and extrapolation across studies. It will facilitate interpretation while supporting analytical advancement and allow clear and concise measurement reporting across a broad range of confidences. https://doi.org/10.1289/EHP15465.
Authors
- Robert O. Wright (ORCID: https://orcid.org/0000-0003-1180-6459)
- Lauren M. Petrick (ORCID: https://orcid.org/0000-0003-3493-7419)
- Amith S. Maroli (ORCID: https://orcid.org/0000-0002-0647-0316)
- Syam S. Andra (ORCID: https://orcid.org/0000-0003-2839-6417)
- Susan L. Teitelbaum (ORCID: https://orcid.org/0000-0002-2190-1575)
- Julio Alberto Landero Figueroa (ORCID: https://orcid.org/0000-0001-8641-0497)
- Mary S. Wolff (ORCID: https://orcid.org/0000-0003-2856-3844)
- Manish Arora (ORCID: https://orcid.org/0000-0002-3350-4657)
- David Achaintre (ORCID: https://orcid.org/0000-0002-5566-3130)
- Priyanthi S. Dessanayake
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1289/ehp15465
- Citations
- 2
- Primary Topic
- Pesticide Residue Analysis and Safety
- Type
- article
- Field-Weighted Citation Impact
- 2.32