C-FOS promotes the formation of neutrophil extracellular traps and the recruitment of neutrophils in lung metastasis of triple-negative breast cancer
In summary, this study demonstrates that the ROS-p38-cFOS-PAD4 axis can increase NET formation in TNBC and promote the expression of inflammatory factors, facilitating neutrophil recruitment. Therefore, targeting this pathway may help inform new therapeutic strategies and provide new insights for immunotherapy in TNBC.
Authors
- Weiyang Tao (ORCID: https://orcid.org/0000-0003-0011-6516)
- Yu Tong (ORCID: https://orcid.org/0000-0001-6295-318X)
- Liangjun Lu (ORCID: https://orcid.org/0000-0002-6036-5103)
- Peng Xu (ORCID: https://orcid.org/0000-0002-9830-5915)
- Hongyue Wang (ORCID: https://orcid.org/0000-0002-4473-1353)
- Ru Yang
- Juntong Du (ORCID: https://orcid.org/0009-0001-4381-5280)
- Lizhi Teng (ORCID: https://orcid.org/0009-0005-0950-4656)
- Jiangnan Liu (ORCID: https://orcid.org/0000-0002-3086-7567)
- Shuai Yan (ORCID: https://orcid.org/0000-0003-0650-1837)
- Yuhan Dong (ORCID: https://orcid.org/0000-0003-4205-6881)
- Wenxi Zhao
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s13046-025-03370-2
- Citations
- 13
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.37