Pamoic acid and carbenoxolone specifically inhibit CRISPR/Cas9 in bacteria, mammalian cells, and mice in a DNA topology-specific manner
These pharmacologically selective inhibitors and new mechanisms offer new tools for controlling the DNA-topology selective activity of Cas9.
Authors
- Yuxuan Zhang (ORCID: https://orcid.org/0000-0001-9407-9589)
- Jiaqi Chen (ORCID: https://orcid.org/0000-0002-1582-3195)
- Wentao Zou (ORCID: https://orcid.org/0009-0003-0901-7466)
- Youtian Hu (ORCID: https://orcid.org/0000-0002-8163-9724)
- Fang Wu
- Yueyang Zhou
Institutions
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s13059-025-03521-w
- Citations
- 1
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China