DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation
Our comprehensive study of DNA methylation in the acinar-ductal metaplasia transition state links epigenetic memory to cancer-related cell plasticity even in the absence of oncogenic mutation.
Authors
- Patrick Cahan (ORCID: https://orcid.org/0000-0003-3652-2540)
- Adrian Idrizi (ORCID: https://orcid.org/0009-0005-3225-9249)
- Rakel Tryggvadóttir (ORCID: https://orcid.org/0000-0003-0225-9086)
- Hongkai Ji (ORCID: https://orcid.org/0000-0002-6480-0141)
- Weiqiang Zhou (ORCID: https://orcid.org/0000-0001-9396-9571)
- Emily K.W. Lo (ORCID: https://orcid.org/0000-0002-0449-8083)
- Wenpin Hou (ORCID: https://orcid.org/0000-0003-0972-2192)
- Andrew P. Feinberg (ORCID: https://orcid.org/0000-0002-8364-1991)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s13073-025-01452-6
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09