Creatine metabolism in psychosis and catatonia: A case report and review of the literature

In the below case report, we describe the development of psychotic and catatonic symptoms in an individual with Arginine-Glycine-Amindinotransferase (AGAT) deficiency, requiring creatine supplementation. We have conducted a literature review and to our knowledge this is the first documented instance of psychiatric symptoms of this kind developing in an individual with AGAT deficiency. This case provides clinical support for the role of brain creatine metabolism in the development of psychotic and catatonic symptoms.