Thalamic iron in multiple sclerosis: Waning support for the early-rise late-decline hypothesis
Our findings contradict the "early rise" hypothesis of thalamic iron levels in pwMS. The consistency of our results across multiple analyses suggests that QSM processing artifacts are unlikely to explain previous reports of increased thalamic iron. Instead, these variations may stem from demographic or clinical differences, such as geographical factors and treatment regimens.
Authors
- Bianca Weinstock-Guttman
- Jack A. Reeves (ORCID: https://orcid.org/0009-0002-4079-5664)
- Ferdinand Schweser (ORCID: https://orcid.org/0000-0003-0399-9211)
- Michael G. Dwyer (ORCID: https://orcid.org/0000-0003-4684-4658)
- Dejan Jakimovski (ORCID: https://orcid.org/0000-0001-7114-4958)
- Niels Bergsland (ORCID: https://orcid.org/0000-0002-7792-0433)
- Fahad Salman (ORCID: https://orcid.org/0009-0000-3873-2301)
- Robert Zivadinov (ORCID: https://orcid.org/0000-0002-7799-1485)
- Abhisri Ramesh
Institutions
- Mohawk Valley Community College (US)
- Mohawk Valley Psychiatric Center (US)
- Buffalo Psychiatric Center (US)
- Jacobs Institute (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103771
- Citations
- 2
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Science Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences