Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids
Xiaozhiling injection exerts its therapeutic effects on internal hemorrhoids by promoting collagen synthesis and secretion in fibroblasts. After Xiaozhiling intervention, the Sphk1-S1P pathway can be activated to promote fibrosis.
Authors
- Y. Cheng (ORCID: https://orcid.org/0009-0007-4791-0051)
- Zhenguo Xu
- Xianbao Liu (ORCID: https://orcid.org/0000-0003-1556-9198)
- Z Li
- Minhui Ke (ORCID: https://orcid.org/0000-0003-0930-8901)
- Shuyan Huang (ORCID: https://orcid.org/0000-0002-7050-9553)
- Xiaxia Zheng
- Weigan Lin
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Surgery
- Published
- 2025-03-29
- DOI
- https://doi.org/10.4240/wjgs.v17.i4.103494
- Primary Topic
- Anorectal Disease Treatments and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00