Shexiang Tongxin Dropping Pills attenuate ischemic microvascular dysfunction via suppressing P66Shc-mediated mitochondrial respiration deficits
STDP facilitated CSE expression and promoted H<sub>2</sub>S production, contributing to the inactivation of P66shc by suppressing its expression and increasing its sulfhydration. This process impeded P66Shc translocation to mitochondria, subsequently restoring mitochondrial respiration and alleviating IS-induced cerebral microvascular endothelial dysfunction.
Authors
- Xiaojie Huang (ORCID: https://orcid.org/0000-0002-5045-9202)
- Wei Wanga
- Miao Zhang (ORCID: https://orcid.org/0009-0009-1094-0972)
- Yang Chen (ORCID: https://orcid.org/0000-0003-0206-1889)
- Jing Feng (ORCID: https://orcid.org/0000-0001-6726-7912)
- Ru Huang (ORCID: https://orcid.org/0000-0002-8146-4821)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Zeyu Chen (ORCID: https://orcid.org/0009-0002-3871-3316)
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.jep.2025.119664
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.38