Research and Analysis of Drug Resistance Mechanism of HDACi in the Treatment of Skin Melanoma

Histone deacetylase inhibitors (HDACi) have shown potential as an epigenetic therapy in various cancer treatments. However, its application in the treatment of skin melanoma faces the challenge of drug resistance. This article reviews the drug resistance mechanism of HDACi in the treatment of skin melanoma, analyzes the mechanism of action of HDACi, the drug resistance characteristics of melanoma, the drug resistance mechanism of HDACi in the treatment of melanoma, and potential solutions to drug resistance, aiming to provide reference for the further application of HDACi in the treatment of skin melanoma.