Bucillamine-induced Yellow Nail Syndrome with Chylothorax
Yellow nail syndrome (YNS), a rare condition characterized by thickened yellow nails, lymphedema, and respiratory manifestations, is rarely caused by bucillamine, an anti-rheumatic agent. Respiratory manifestations of YNS include chylothorax in 18.8-22% of patients with pleural effusion. We herein report the first case of bucillamine-induced YNS with chylothorax. Lymphangiography revealed narrowing of the lymphatic vessels and stagnation of the lymphatic fluid, suggesting impaired lymphatic drainage. The chylothorax persisted despite the discontinuation of bucillamine. The present case illustrates that bucillamine can cause irreversible lymphatic impairment and chylothorax.
Authors
- Kosei Yonezawa
- Tomoyuki Kakugawa (ORCID: https://orcid.org/0000-0003-1339-1031)
- Maki Asami‐Noyama (ORCID: https://orcid.org/0000-0001-5218-6132)
- Keiji Oishi (ORCID: https://orcid.org/0000-0003-4230-0450)
- Kazuki Hamada (ORCID: https://orcid.org/0000-0002-5082-1486)
- Yoriyuki Murata (ORCID: https://orcid.org/0000-0001-8652-2579)
- Tsunahiko Hirano (ORCID: https://orcid.org/0000-0002-5475-0806)
- Nobutaka Edakuni
- Kazuki Matsuda
- Yoshikazu Yamaji (ORCID: https://orcid.org/0000-0002-2847-3702)
- Yukari Hisamoto
- Koji Narikiyo
- Keita Murakawa
- Kazuto Matsunaga (ORCID: https://orcid.org/0000-0002-0514-3241)
- Toshiaki Utsunomiya
- Syuichiro Ohata
- Taiga Kobayashi
Institutions
- Tokuyama (Japan) (JP)
- Yamaguchi University (JP)
- National Sanyo Hospital (JP)
- Japan Community Healthcare Organization (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.2169/internalmedicine.4935-24
- Citations
- 1
- Primary Topic
- Lymphatic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01