Revisiting the Loa loa microfilaremia thresholds above which serious adverse events may occur with ivermectin treatment
Our study suggests that IVM should be used with caution for males or individuals in specific age categories with a high L. loa MFD. For these high risk groups, lowering the thresholds to 8000 mf/mL should be considered. The increased risk in males requires further investigation to understand the pathophysiological phenomena involved that are crucial to prevent and manage SAEs.
Authors
- Joseph Kamgno (ORCID: https://orcid.org/0000-0003-1572-3490)
- Joël Fokom Domgue (ORCID: https://orcid.org/0000-0002-4722-9262)
- Jacques Gardon (ORCID: https://orcid.org/0000-0002-0570-634X)
- Charlotte Boullé (ORCID: https://orcid.org/0000-0002-3800-6315)
- Cédric B. Chesnais (ORCID: https://orcid.org/0000-0002-8779-977X)
- Michel Boussinesq (ORCID: https://orcid.org/0000-0001-6312-0681)
- Sébastien D. S. Pion (ORCID: https://orcid.org/0000-0002-9468-7020)
- Nathalie Gardon-Wendel
Institutions
- Université de Yaoundé I (CM)
- The University of Texas MD Anderson Cancer Center (US)
- Inserm (FR)
- Université de Montpellier (FR)
- Laboratoire HydroSciences Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Centre Pasteur du Cameroun (CM)
- Ministry of Scientific Research and Innovation (CM)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1371/journal.pntd.0012957
- Citations
- 2
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Fondation Bettencourt Schueller