Reconfigurable logic operations for fluorescent sensing of drug resistant and/or hypoxic cancer cells
Precision diagnosis is of great importance and can be achievable through information processing sensors. A distyryl pyridinium BODIPY decorated with nitroreductase and esterase enzyme responsive modules is shown to display configurable fluorescence read out upon enzyme-catalysed elimination reaction creating pyridine distyryl BODIPYs. Discrimination of the cellular profile, <i>i.e.</i> drug resistance and hypoxic microenvironment, is achieved with a single molecule through reconfigurable molecular logic gate operations.
Authors
- Sündüs Erbaş-Çakmak (ORCID: https://orcid.org/0000-0003-4168-8377)
- Fatma Seçer Çelik (ORCID: https://orcid.org/0000-0001-5619-8958)
- Safaa Altveş (ORCID: https://orcid.org/0000-0001-5873-2085)
- İmran Verirsen (ORCID: https://orcid.org/0000-0002-2042-5714)
- Emin Sahin
- Aminesena Baser (ORCID: https://orcid.org/0000-0001-8018-357X)
- Nezahat Gokce Ozsamur (ORCID: https://orcid.org/0000-0003-0866-9617)
Institutions
- Konya Food and Agriculture University (TR)
- Necmettin Erbakan University (TR)
Publication Details
- Journal
- Journal of Materials Chemistry B
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5tb00193e
- Citations
- 3
- Primary Topic
- Analytical Chemistry and Sensors
- Type
- article
- Field-Weighted Citation Impact
- 2.21