Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantification of Bone Marrow Aging and Radiation Effects in Mice
These findings highlight PDFF-MRI's potential as a non-invasive, real-time, in vivo biomarker for quantitatively assessing the BM fat fraction in preclinical studies, particularly in studies evaluating the effects of aging, disease progression, and cytotoxic cancer therapies, including chemotherapy and radiation.
Authors
- Weidong Hu (ORCID: https://orcid.org/0000-0003-3911-5262)
- A. Camacho (ORCID: https://orcid.org/0000-0003-1138-1729)
- Guy Storme (ORCID: https://orcid.org/0000-0003-0806-7915)
- Malakeh Malekzadeh
- Hemendra Ghimire
- Marco Andrea Zampini (ORCID: https://orcid.org/0000-0002-3411-1900)
- Monzr M. Al Malki (ORCID: https://orcid.org/0000-0001-8226-471X)
- Natalia Baran (ORCID: https://orcid.org/0000-0003-0618-4798)
- Ji Eun Lim
- Srideshikan Sargur Madabushi (ORCID: https://orcid.org/0000-0002-1087-6044)
- Susanta Hui (ORCID: https://orcid.org/0000-0002-1394-3724)
Institutions
- University of Bern (CH)
- City Of Hope National Medical Center (US)
- University of Antwerp (BE)
- University Hospital of Bern (CH)
- Instytut Hematologii i Transfuzjologi (PL)
- City of Hope (US)
- Universitair Ziekenhuis Brussel (BE)
- Materials Solutions (United Kingdom) (GB)
Publication Details
- Journal
- Bioengineering
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3390/bioengineering12040349
- Citations
- 2
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- National Institutes of Health