Corticotropin-releasing hormone receptor-1 antagonist attenuates visceral hypersensitivity induced by trinitrobenzene sulfonic acid colitis and maternal separation in rats
These findings suggest that the combination of previous colitis and early life stress induce visceral hypersensitivity, and that the CRH-R1 pathway may play a role in this sensitization.
Authors
- Motoyori Kanazawa (ORCID: https://orcid.org/0000-0003-1953-3336)
- Shin Fukudo (ORCID: https://orcid.org/0000-0003-2265-0349)
- Kumi Nakaya (ORCID: https://orcid.org/0000-0003-0027-6667)
- Ryoko Hasegawa
Institutions
- Tohoku University (JP)
- Ishinomaki Senshu University (JP)
- Tohoku University Hospital (JP)
- Tohoku Medical Megabank Organization (JP)
Publication Details
- Journal
- BioPsychoSocial Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1186/s13030-025-00324-0
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Smoking Research Foundation
- Japan Society for the Promotion of Science