Allicin ameliorates acute myocardial infarction in rats by modulating calcium homeostasis in cardiomyocytes through the induction of hydrogen sulfide production
Our study presents novel evidence demonstrating that allicin modulates Ca<sup>2+</sup> homeostasis in cardiomyocytes by stimulating H<sub>2</sub>S production, thereby conferring protection against AMI. Furthermore, the protective effects of allicin are partly mediated by, but not solely reliant on, the generation of H<sub>2</sub>S. These findings not only provide mechanistic insights into the anti-AMI effects of allicin but also underscore its therapeutic promise.
Authors
- Rongmei Shi
- Juan Wang (ORCID: https://orcid.org/0000-0002-5244-256X)
- Ruiting Liu (ORCID: https://orcid.org/0009-0000-3348-3975)
- Xu Shaojun
- Xinxia Li (ORCID: https://orcid.org/0000-0001-7728-6914)
- Yikui Li (ORCID: https://orcid.org/0000-0002-7449-9786)
- Weiyu Liu (ORCID: https://orcid.org/0000-0002-0360-5502)
- Zhao Le
- Jinyan Zhang (ORCID: https://orcid.org/0009-0001-2001-1773)
Institutions
- Xinjiang Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fphar.2025.1557685
- Citations
- 1
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.11