Association Between Risk of Relapse and Type of Surgical Procedure for Raynaud’s Disease

BACKGROUND Raynaud's syndrome, a vascular dysfunction disorder characterized by paroxysmal spasms of small arteries in the extremities, has long attracted attention in the medical field. Despite the absence of a comprehensive understanding of its etiology, this condition is considered to be associated with impaired vascular endothelial function, neuromodulation disorders, and genetic factors. MATERIAL AND METHODS We conducted an analysis of data from 110 eligible patients, with approval from the Ethics Committee of our hospital. We assessed medical records, the Visual Analog Scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Disabilities of the Arm, Shoulder, and Hand (DASH) scores, and adverse events linked to relapse. Survival analyses were carried out using the Kaplan-Meier method. Univariate and multivariate analyses were employed to identify factors associated with RD and to construct a prognostic line chart for postoperative recurrence. RESULTS In the 6-month survival analysis model, the following factors demonstrated statistical significance in multivariate analysis: primary disease (HR: 1.718; 95% CI: 1.044-2.829), surgical approach (HR: 0.454; 95% CI: 0.272-0.760), perfusion index difference (HR: 0.870; 95% CI: 0.76-0.994), and peripheral temperature difference (HR: 0.755; 95% CI: 0.615-0.928). In the 1-year survival analysis model, statistically significant factors in multivariate analysis included primary disease (HR: 1.881; 95% CI: 1.125-3.145), surgical approach (HR: 0.489; 95% CI: 0.291-0.821), perfusion index difference (HR: 0.866; 95% CI: 0.759-0.989), and peripheral temperature difference (HR: 0.757; 95% CI: 0.618-0.928). CONCLUSIONS Independent risk factors for postoperative recurrence of Reynaud's syndrome include the primary disease, surgical approach, changes in perfusion indices, and changes in peripheral temperature.