Asymmetric oxidative rearrangement of indoles enabled by dual catalysis with <i>in situ</i> generated acyl hypoiodite and chiral phosphoric acid
A dual catalytic asymmetric oxidative rearrangement of indoles via traceless halonium intermediates. This halide-catalyzed method features excellent enantioselectivity and broad functional group tolerance, including late-stage complex targets.
Authors
- Haowei Gao
- Lei Shi (ORCID: https://orcid.org/0000-0002-6865-1104)
- Xihui Yang
Institutions
- Harbin Institute of Technology (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00302d
- Citations
- 2
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province