Contribution of smoking to the global burden of bladder cancer from 1990 to 2021 and projections to 2046

Despite a decrease in the ASRs of smoking-attributable bladder cancer, the absolute burden has increased and is expected to continue growing. Therefore, continuous and targeted tobacco control measures and medical strategies are needed, especially for developed regions, the elderly, and male populations. And due to the unique mechanisms by which tobacco causes disease, the youth and female populations should not be neglected.