Comprehensive observation of histone lysine lactylation during gametogenesis of <i>Drosophila melanogaster</i>
Our results revealed that histone lysine lactylation is predominantly present in transcriptionally repressive meiotic chromatin, which contradicts the previously reported function of histone lactylation in transcriptional activation. This study, therefore, provides the first fundamental information to understand the role of histone lysine lactylation in the germline and repressive chromatin.
Authors
- Ban Sato
- Ryoichiro Kageyama (ORCID: https://orcid.org/0000-0002-5985-1120)
- Kenji Miyado
- Daisuke Saito (ORCID: https://orcid.org/0000-0002-5999-2505)
- Yoshiki Hayashi (ORCID: https://orcid.org/0000-0002-8966-8730)
- Satoru Kobayashi (ORCID: https://orcid.org/0000-0003-1127-5328)
- Natsuko Kawano (ORCID: https://orcid.org/0000-0001-5790-8704)
Institutions
- Kyushu University (JP)
- University of Tsukuba (JP)
- Meiji University (JP)
- National Center For Child Health and Development (JP)
Publication Details
- Journal
- Developmental Dynamics
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1002/dvdy.70010
- Citations
- 2
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.61