Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer

Exosomes derived from HepG2 cells transfected with shPDGF-D prevent normal fibroblasts from transforming into CAFs, thus inhibiting angiogenesis and EMT of liver cancer.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2025-03-21
DOI
https://doi.org/10.31083/fbl26045
Citations
1
Primary Topic
Extracellular vesicles in disease
Type
article
Field-Weighted Citation Impact
0.81
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article

Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer

Jun-Chao Xue, Liu-Shen-Yan Yu, Yanyan Wu, Hanyu Zhou
1 citations
Frontiers in Bioscience-Landmark
Extracellular vesicles in disease
0.81
article

Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer

Jun-Chao Xue, Liu-Shen-Yan Yu, Yanyan Wu, Hanyu Zhou
article en
1 citations

Abstract

Exosomes derived from HepG2 cells transfected with shPDGF-D prevent normal fibroblasts from transforming into CAFs, thus inhibiting angiogenesis and EMT of liver cancer.

Frontiers in Bioscience-LandmarkVol. 30(3)
Tongde Hospital of Zhejiang Province (CN)
Good health and well-being
Openalex Percentile: Top 30%
Extracellular vesicles in disease
0.81
DOIOpen Access PDFOpenAlex
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Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer — Jun-Chao Xue, Liu-Shen-Yan Yu, et al. · Frontiers in Bioscience-Landmark (2025) | TGRS Research Map | TGRS