Plasma Lipidomics, Gut Microbiota Profile, and Phenotype of Adipose Tissue in an ApoE-/- Mouse Model of Plaque Instability
This study established an <i>ApoE</i><sup>-/-</sup> mouse atherosclerotic vulnerable plaque model using a multi-index evaluation method. Adipogenic disorders, dysregulation of lipid metabolism at the molecular level, and increasing harmful gut microbiota are significant risk factors for vulnerable plaques, with sphingolipid metabolism receiving the most attention.
Authors
- Pengwei Zhao (ORCID: https://orcid.org/0000-0002-2526-5705)
- Guanlin Yang
- Xuan Zhang (ORCID: https://orcid.org/0009-0008-5203-0355)
- Jingkun Lu
- Qiong Zhai
- Yuewu Wang (ORCID: https://orcid.org/0000-0002-1158-879X)
- Lili Bao (ORCID: https://orcid.org/0000-0003-4498-5932)
- Fangyuan Liang
- Xin Tan
Institutions
- Zaozhuang Municipal Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-03-21
- DOI
- https://doi.org/10.31083/fbl27236
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China