Scorpion Venom and Its Different Peptides Aid in Treatment Focusing on Cancer Disease with the Mechanism of Action

Animal venoms, especially those from scorpions, have garnered interest for their potential therapeutic uses. Scorpion venom is a complex mixture of bioactive compounds, including neurotoxins, enzymes, enzyme inhibitors, and peptides. These peptides have shown promise in pharmacological applications due to their high selectivity and relatively safe mechanisms of action. In this review, we focused on cancer, one of the leading causes of death worldwide, and explored the potential of scorpion venom peptides as promising therapeutic agents in cancer treatment. Despite significant advancements in cancer therapy, many cases remain reliant on palliative care, particularly for treatment-resistant cancer types. Scorpion venom peptides, with their specific and targeted mechanisms of action, exhibit potential as novel anticancer agents. These peptides have demonstrated the ability to selectively target cancer cells, inhibit tumor proliferation, and modulate immune responses, positioning them as valuable candidates for the development of more effective therapies. Previous studies have highlighted that certain venom-derived peptides can suppress tumor growth and metastasis, underscoring their potential to enhance clinical outcomes. Consequently, scorpion venom offers new perspectives and avenues for developing next-generation cancertreatments.Cite this article as: Amen, RA, & Abd-Ellatef, GEF. Scorpion venom and its different peptides aid in treatment focusing on cancer disease with the mechanism of action. Trends Pharm. 2024, 1, 11, doi: 10.5152/TrendsPharm.2024.24011.