Transcription Factor FOSL1 Promotes Cisplatin Resistance in Non-Small Cell Lung Cancer Cells by Modulating the Wnt3a/β-Catenin Signaling through Upregulation of PLIN3 Expression
This study demonstrates that PLIN3 contributes to DDP resistance in LUAD by activating the Wnt3a/β-catenin signaling pathway, with FOSL1 acting as a critical upstream regulator. Targeting the FOSL1/PLIN3/Wnt/β-catenin axis may provide a promising therapeutic strategy for overcoming chemoresistance in LUAD.
Authors
- Min Rao (ORCID: https://orcid.org/0000-0001-8330-260X)
- Bin Shen (ORCID: https://orcid.org/0000-0002-8946-8448)
- Delin Xia (ORCID: https://orcid.org/0000-0002-2882-287X)
- Jianzeng Dong (ORCID: https://orcid.org/0000-0001-7299-7805)
- Wenxue Tong (ORCID: https://orcid.org/0000-0003-3462-2740)
- Jin Li (ORCID: https://orcid.org/0000-0002-4538-4285)
- Hong Wang (ORCID: https://orcid.org/0000-0002-6192-3082)
- Chenxing Wang
- Dongmei Zhu (ORCID: https://orcid.org/0000-0002-2557-1243)
- Yaohua Hu (ORCID: https://orcid.org/0000-0002-2149-3532)
- Zhigang Cai (ORCID: https://orcid.org/0000-0002-3558-9391)
- Jianjun Sun
- Haibo Wu
Institutions
- PLA Navy General Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-03-19
- DOI
- https://doi.org/10.31083/fbl26898
- Citations
- 2
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.22