High-Intensity Interval Training Decreases Circulating HMGB1 in Individuals with Insulin Resistance: Plasma Lipidomics Correlate with Associated Cardiometabolic Benefits
Six weeks of BW-HIIT exercise can improve cardiometabolic health, anti-inflammatory markers, hormones, and insulin sensitivity in human and mouse models undergoing exercise. Changes in circulating HMBG1 levels following BW-HIIT exercise make HMGB1 a suitable marker for cardiometabolic disease, potentiating its role beyond an alarmin. Further studies are needed to confirm these effects and to elucidate the underlying physiological mechanisms.
Authors
- Prabu Paramasivam (ORCID: https://orcid.org/0000-0002-8626-1601)
- Roberto Mota (ORCID: https://orcid.org/0000-0002-4911-0687)
- Lara C. Kovell (ORCID: https://orcid.org/0000-0002-7919-2361)
- Quiteria Jacquez
- Fabiano Trigueiro Amorim (ORCID: https://orcid.org/0000-0003-2936-4484)
- Gabriela Martinez Bravo (ORCID: https://orcid.org/0009-0002-5167-8041)
- Huayu Zheng (ORCID: https://orcid.org/0000-0001-7355-0247)
- Gabriella F. Bellissimo
Institutions
- University of Massachusetts Chan Medical School (US)
- University of New Mexico (US)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-03-21
- DOI
- https://doi.org/10.31083/fbl31396
- Citations
- 5
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 6.59
Funders
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Environmental Health Sciences
- National Center for Advancing Translational Sciences