cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy
Radiation can improve cardiac function, decrease hypertrophy of myocardial cells, and induce oxidative stress. This oxidative stress results in the leakage of mitochondrial DNA (mtDNA), which subsequently activates the cGAS/STING/NLRP3 signalling pathway, culminating in pyroptosis.
Authors
- Jian Li (ORCID: https://orcid.org/0000-0001-6935-7751)
- Huiyang Li
- Haiming Shi
- Xin Wang (ORCID: https://orcid.org/0000-0001-7191-6145)
- Xinping Luo
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-03-05
- DOI
- https://doi.org/10.31083/fbl26084
- Citations
- 6
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 8.33