Preclinical Evaluation of a Novel Cryo Renal Denervation System
The objective of this study was to demonstrate the safety and efficacy of a novel cryo renal denervation system (Cryo-RDN) in a porcine model. Procedural and mid-term safety of the Cryo-RDN was demonstrated. Efficacy of the cryoablation was evidenced by histological findings in the renal arteries and reduced renal tissue norepinephrine concentrations on the treated sides. Despite some morphological nerve repair observed between 7 and 28 days, the greater renal norepinephrine suppression in the 28-day animals suggests irreversibly ablated sympathetic nerves.
Authors
- Lucas Lauder (ORCID: https://orcid.org/0000-0003-1434-9556)
- Hanno U. Klemm
- Alicia Beele (ORCID: https://orcid.org/0000-0001-5629-4595)
- Natascha Drude (ORCID: https://orcid.org/0000-0002-7153-2894)
- Felix Mahfoud (ORCID: https://orcid.org/0000-0002-4425-549X)
- Jo Adaway (ORCID: https://orcid.org/0000-0003-4352-3410)
- Florian Krackhardt (ORCID: https://orcid.org/0000-0001-5965-8817)
- W. Haider
- Konstantinos P Tsioufis (ORCID: https://orcid.org/0000-0002-7636-6725)
- Brian George Keevil (ORCID: https://orcid.org/0000-0002-0684-9318)
- Michael Joner (ORCID: https://orcid.org/0000-0002-2971-8310)
- Léa Wild
Institutions
- National and Kapodistrian University of Athens (GR)
- University Hospital of Basel (CH)
- Manchester University NHS Foundation Trust (GB)
- Deutsches Herzzentrum der Charité (DE)
- Institut für Tier-, Natur- und Umweltethik (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Deutsches Herzzentrum München (DE)
- Medicines Evaluation Unit (GB)
- Charité - Universitätsmedizin Berlin (DE)
- CryoLife (United States) (US)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.jacbts.2025.01.014
- Citations
- 2
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78