Cs<sub>2</sub>CO<sub>3</sub>-Mediated Annulation of Cyclopropane-1,1-dicarbonitriles with <i>o</i>-Benzenediamines: Access to Substituted 2-Aminoquinoxalines
The Cs<sub>2</sub>CO<sub>3</sub>-mediated formal (4 + 2) cascade annulation strategy for the synthesis of 2-aminoquinoxalines has been developed using D-A cyclopropanes and <i>o</i>-benzenediamines as the substrates. The protocol provides an efficient method of accessing a broad range of 2-aminoquinoxaline derivatives in good to excellent yields with good functional-group tolerance.
Authors
- Cunde Wang (ORCID: https://orcid.org/0000-0001-5561-979X)
- Haiwen Li (ORCID: https://orcid.org/0000-0001-7223-1754)
- Xinyi Wan (ORCID: https://orcid.org/0000-0001-6935-0218)
- Wenzhe Cheng
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1021/acs.joc.4c03160
- Citations
- 1
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Priority Academic Program Development of Jiangsu Higher Education Institutions