Decoding Genomic Diversity to Guide Tumor Lesion‐Specific Treatment of Multifocal Hepatocellular Carcinoma
The study shows substantial inter-tumoral heterogeneity in multifocal HCC, indicating the necessity for comprehensive molecular profiling for tailored treatment strategies. Divergent actionable mutations across lesions suggest that a uniform treatment approach may not be effective in some patients with multifocal HCC.
Authors
- Yosuke Hirotsu (ORCID: https://orcid.org/0000-0002-8002-834X)
- Yuji Iimuro
- Ryosuke Tajiri (ORCID: https://orcid.org/0000-0003-4914-0787)
- Shuntaro Obi (ORCID: https://orcid.org/0000-0003-3525-4708)
- Kenji Amemiya (ORCID: https://orcid.org/0000-0003-4223-0528)
- Masao Omata (ORCID: https://orcid.org/0000-0001-7977-1497)
- Hitoshi Mochizuki (ORCID: https://orcid.org/0000-0002-1145-0969)
- Toshio Oyama
Institutions
- Teikyo University Chiba Medical Center (JP)
- Yamanashi Prefectural Central Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1002/cam4.70814
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Takeda Science Foundation
- Uehara Memorial Foundation
- Kato Memorial Bioscience Foundation
- Yasuda Memorial Medical Foundation
- Japan Society for the Promotion of Science