History of mental comorbidities and their relationships with drinking milestones, hazardous drug use, suicide attempts, and the <i>ADH1B</i> and <i>ALDH2</i> genotypes in 4116 Japanese men with alcohol dependence: An exploratory study
Mental comorbidities and a history of suicide attempts were frequent in Japanese patients with AD. Risk factors for AD (ADH1B*1/*1, smoking, early initiation of drinking) were negatively associated with the risk of comorbidities, suggesting interactions between comorbidities and AD risk factors. Insomnia was positively associated with the inactive ALDH2*1/*2. AD patients with mental comorbidities require multifaceted interventions, including suicide prevention.
Authors
- Takanobu Matsuzaki (ORCID: https://orcid.org/0000-0002-5625-0418)
- Tsuyoshi Takimura
- Yosuke Yumoto (ORCID: https://orcid.org/0000-0002-4837-9174)
- Ruriko Minobe
- Tomomi Toyama (ORCID: https://orcid.org/0009-0002-4471-5799)
- Junichi Yoneda
- Akira Yokoyama (ORCID: https://orcid.org/0000-0003-4636-5032)
- Akira Yokoyama (ORCID: https://orcid.org/0000-0003-1869-1359)
- Sachio Matsushita (ORCID: https://orcid.org/0000-0002-2439-7984)
- Kotaro Nishimura (ORCID: https://orcid.org/0000-0003-3972-6952)
- Mitsuru Kimura
Institutions
- National Institute of Public Health (JP)
- Kurihama Medical and Addiction Center (JP)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1111/acer.70014
- Citations
- 1
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.47