Therapeutic targeting of the Tryptophan-Kynurenine Axis for HTR-8/SVneo trophoblast proliferation and migration in unexplained recurrent spontaneous abortion
Our study reveals a novel molecular mechanism by which Trp metabolism regulates HTR-8 cell function, suggesting that modulating IDO1 activity may represent a therapeutic strategy to improve trophoblast function and pregnancy outcomes in RSA.
Authors
- Xiliang Ni (ORCID: https://orcid.org/0000-0003-3828-1840)
- Yongxiang Yin (ORCID: https://orcid.org/0000-0002-2180-5647)
- Pingping Jin
- Ye Shen (ORCID: https://orcid.org/0000-0001-6012-7183)
- Daozhen Chen (ORCID: https://orcid.org/0000-0003-4791-8065)
- Xinyi Lu (ORCID: https://orcid.org/0000-0001-5961-6625)
- Yun Zhang (ORCID: https://orcid.org/0000-0002-6309-2470)
- Lu Wang (ORCID: https://orcid.org/0009-0009-5254-3000)
- Yan Chen (ORCID: https://orcid.org/0000-0002-6873-8648)
- Yu Chen (ORCID: https://orcid.org/0000-0003-2818-5791)
- Lan Yang (ORCID: https://orcid.org/0000-0002-4480-2182)
Institutions
- Jiangnan University (CN)
- Women's Hospital (US)
Publication Details
- Journal
- Biology of Reproduction
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1093/biolre/ioaf040
- Citations
- 1
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 1.88