Nasal cytological evidence of chronic inflammation in the olfactory cleft in post-viral olfactory dysfunction
Persistent post-viral olfactory dysfunction is associated with sustained immune activation and epithelial damage localized to the olfactory cleft. Elevated lymphocytes, neutrophils, and ciliocytophthoria emphasize the role of chronic inflammation in the pathogenesis of prolonged olfactory deficits. These findings highlight the potential utility of targeted therapies to modulate immune responses and promote olfactory recovery in affected patients.
Authors
- Sergio Bernardini (ORCID: https://orcid.org/0000-0003-1984-6834)
- Marzia Nuccetelli (ORCID: https://orcid.org/0000-0002-8702-1116)
- Simonetta Masieri (ORCID: https://orcid.org/0000-0003-0423-9505)
- Gianluca Velletrani (ORCID: https://orcid.org/0000-0002-0822-6587)
- Stefano Di Girolamo (ORCID: https://orcid.org/0000-0002-6419-9704)
- Beatrice Francavilla (ORCID: https://orcid.org/0000-0002-4788-7310)
- Denise Fiorelli (ORCID: https://orcid.org/0000-0001-6910-6995)
Institutions
- University of Rome Tor Vergata (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- European Archives of Oto-Rhino-Laryngology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1007/s00405-025-09302-2
- Citations
- 2
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Università degli Studi di Roma Tor Vergata