Intra‐ and Interobserver Variability of Acute Food–Induced Reactions During Confocal Laser Endomicroscopy: An International Multicenter Validation Study
Our study showed a substantial to perfect intraobserver agreement and a substantial interobserver agreement for the judgment of acute food-triggered disruption of the duodenal epithelial barrier by pCLE, confirming that this real-time readout is reliable and reproducible.
Authors
- Yaser Hatem
- Christian Sina (ORCID: https://orcid.org/0000-0001-7640-1220)
- Lukas Michaja Balsiger (ORCID: https://orcid.org/0000-0001-7399-8500)
- Karlien Raymenants (ORCID: https://orcid.org/0000-0003-0520-4734)
- Jan F. Tack (ORCID: https://orcid.org/0000-0002-3206-6704)
- Tom van Gils (ORCID: https://orcid.org/0009-0006-2103-9491)
- Cedric Van de Bruaene (ORCID: https://orcid.org/0000-0002-7823-016X)
- Hans Törnblom (ORCID: https://orcid.org/0000-0003-2117-9874)
- Tim Vanuytsel (ORCID: https://orcid.org/0000-0001-8728-0903)
- Jóhann P. Hreinsson (ORCID: https://orcid.org/0000-0002-0078-3063)
- Magnus Simrén (ORCID: https://orcid.org/0000-0002-1155-1313)
- Amanda Blomsten
- Leïla Juvyns
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Bern (CH)
- Fraunhofer-Einrichtung für Individualisierte Medizintechnik (DE)
- University of Gothenburg (SE)
- University of Lübeck (DE)
- KU Leuven (BE)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1111/nmo.70031
- Citations
- 1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Science Foundation
- Novartis Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bundesministerium für Bildung und Forschung
- Fonds Wetenschappelijk Onderzoek
- Universität zu Lübeck
- Novartis Stiftung für Medizinisch-Biologische Forschung
- Vlaamse regering