TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
We reveal a novel pathway by which TMEM55A regulates alpha cell exocytosis by controlling intracellular PI5P and the F-actin network.
Authors
- Patrick Edward MacDonald (ORCID: https://orcid.org/0000-0002-5439-6288)
- Aliya F Spigelman (ORCID: https://orcid.org/0000-0001-6188-2041)
- Kunimasa Suzuki (ORCID: https://orcid.org/0000-0003-0102-3493)
- Theodore dos Santos (ORCID: https://orcid.org/0000-0002-9761-3609)
- Serge Duckett
- Xiong Liu (ORCID: https://orcid.org/0000-0003-4467-6638)
- Nancy Smith (ORCID: https://orcid.org/0000-0001-6317-7207)
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1007/s00125-025-06411-9
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Diabetes Canada
- Canadian Institutes of Health Research