A rare case of multiple myeloma with double translocations: t(11;14) and t(14;16)
Multiple myeloma is a clonal plasma cell malignancy often characterized by complex cytogenetic abnormalities that influence prognosis and treatment strategies. This report describes a 63-year-old male with kappa light chain multiple myeloma and a rare finding of double translocation involving t(11;14) and t(14;16), detected by FISH analysis. This case emphasizes the clinical implications of such genetic abnormalities and their impact on disease progression and therapeutic decisions.
Authors
- David Glen Coffey (ORCID: https://orcid.org/0000-0003-3544-8836)
- Mina Meseha
- Ping Yang (ORCID: https://orcid.org/0000-0001-5466-8426)
- Vishw Patel
- Kirolos Sekla
Institutions
- Cleveland Clinic (US)
- University of Miami (US)
- Alexandria University (EG)
Publication Details
- Journal
- Journal of Hematopathology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1007/s12308-025-00626-w
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00