METTL3-dependent m6A methylation of circCEACAM5 fuels pancreatic cancer progression through DKC1 activation
METTL3-mediated m6A methylation of circCEACAM5 drives pancreatic cancer progression by increasing DKC1 expression, suggesting potential new therapeutic targets for this aggressive malignancy.
Authors
- Wenxue Sun
- Ben Wei (ORCID: https://orcid.org/0009-0007-4639-0277)
- Zihui Qin
- Wenda Wu (ORCID: https://orcid.org/0009-0003-3307-687X)
- Tushuai Li (ORCID: https://orcid.org/0000-0002-6219-1397)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-9184-0587)
Institutions
- Nanjing Agricultural University (CN)
- Suzhou University of Technology (CN)
- Jining First People's Hospital (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1007/s00018-025-05653-5
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Science and Technology Program of Suzhou