ALADDIN: A Machine Learning Approach to Enhance the Prediction of Significant Fibrosis or Higher in Metabolic Dysfunction-Associated Steatotic Liver Disease
Along with the steatosis-associated fibrosis estimator model developed to target significant fibrosis or higher, ALADDIN-F2-VCTE ( https://aihepatology.shinyapps.io/ALADDIN1 ) uniquely supports a refined noninvasive approach to patient selection for resmetirom without the need for liver biopsy. In addition, ALADDIN-F2-Lab ( https://aihepatology.shinyapps.io/ALADDIN2 ) offers an effective alternative when VCTE is unavailable.
Authors
- Laurent Castéra (ORCID: https://orcid.org/0000-0002-6715-8588)
- Manal F. Abdelmalek (ORCID: https://orcid.org/0000-0002-5001-8618)
- Luis Antonio Díaz (ORCID: https://orcid.org/0000-0002-8540-4930)
- Congxiang Shao (ORCID: https://orcid.org/0000-0001-9628-6426)
- Stephen A. Harrison (ORCID: https://orcid.org/0000-0003-2407-2685)
- Terry Cheuk‐Fung Yip (ORCID: https://orcid.org/0000-0002-1819-2464)
- Winston Dunn (ORCID: https://orcid.org/0000-0002-4246-6998)
- Haya Omeish (ORCID: https://orcid.org/0000-0002-8078-185X)
- Nipun Verma (ORCID: https://orcid.org/0000-0003-4328-0914)
- Juan Pablo Arab (ORCID: https://orcid.org/0000-0002-8561-396X)
- Marco A. Arrese (ORCID: https://orcid.org/0000-0002-0499-4191)
- Naim Alkhouri (ORCID: https://orcid.org/0000-0001-9872-2391)
- Junzhao Ye (ORCID: https://orcid.org/0000-0003-3163-4164)
- Vincent Chen (ORCID: https://orcid.org/0000-0002-0157-6066)
- Matthew Kubina (ORCID: https://orcid.org/0000-0003-3472-0690)
- Bihui Zhong (ORCID: https://orcid.org/0000-0002-3089-8152)
- Julie Dubourg (ORCID: https://orcid.org/0000-0002-5514-8075)
- Ashwani Kumar Singal (ORCID: https://orcid.org/0000-0003-1207-3998)
- Syed‐Mohammed Jafri (ORCID: https://orcid.org/0000-0001-8108-7408)
- Grace Lai–Hung Wong (ORCID: https://orcid.org/0000-0002-2863-9389)
- Leon Anton Adams (ORCID: https://orcid.org/0000-0002-3968-7909)
- Ajay Duseja (ORCID: https://orcid.org/0000-0003-3590-2664)
- Jessica Cristiu (ORCID: https://orcid.org/0009-0008-3295-9407)
- Yousef Almahanna (ORCID: https://orcid.org/0009-0007-9130-8463)
- Amani Bajunayd
- Marina Takawy (ORCID: https://orcid.org/0009-0007-2433-5904)
- Zhengyi Wang
- Vincent Wai‐Sun Wong (ORCID: https://orcid.org/0000-0003-2215-9410)
- Rida Nadeem
- Nicholas Dunn (ORCID: https://orcid.org/0000-0002-9265-8111)
- Sage Robert
Institutions
- Mayo Clinic (US)
- University of Louisville (US)
- Inserm (FR)
- Sun Yat-sen University (CN)
- Pontificia Universidad Católica de Chile (CL)
- Chinese University of Hong Kong (HK)
- The University of Western Australia (AU)
- Virginia Commonwealth University (US)
- Université Paris Cité (FR)
- University of Michigan (US)
- Hôpital Beaujon (FR)
- WinnMed (US)
- Henry Ford Hospital (US)
- University of California San Diego (US)
- University of North Carolina at Pembroke (US)
- University of Oxford (GB)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pinnacle Clinical Research (US)
- Conceptual Mindworks (United States) (US)
- Mayo Clinic in Arizona (US)
- University of Kansas Medical Center (US)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- University of California San Diego Medical Center (US)
- University of Louisville Hospital (US)
- Arizona Liver Health (US)
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.14309/ajg.0000000000003432
- Citations
- 7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.48