Up-regulated microRNAs in blastocoel fluid of human implanted embryos could control circuits of pluripotency and be related to embryo competence
The six miRNAs up-regulated in blastocoel fluid from implanted embryos may represent a functional molecular signature for evaluating blastocyst quality and identifying the most competent embryos. Their evaluation associated with non-invasive preimplantation genetic testing, integrating epigenetic and genomic analyses, could enhance implantation grade and allow for identification of the euploid embryo not able to implant.
Authors
- Carmen Ferrara (ORCID: https://orcid.org/0000-0003-4915-0854)
- Maria Rosaria Campitiello
- E. Kasapi
- Placido Borzì
- Basilio Pecorino (ORCID: https://orcid.org/0000-0001-6987-4193)
- Domenico Valerio
- Cristina Barbagallo (ORCID: https://orcid.org/0000-0002-6769-4516)
- Michael Feichtinger (ORCID: https://orcid.org/0000-0001-6453-9281)
- Paolo Scollo (ORCID: https://orcid.org/0000-0001-6275-7488)
- Luca Carli (ORCID: https://orcid.org/0009-0000-1992-5220)
- Rosalia Battaglia (ORCID: https://orcid.org/0000-0002-4868-3045)
- Michele Purrello (ORCID: https://orcid.org/0000-0001-8873-3660)
- Davide Barbagallo (ORCID: https://orcid.org/0000-0001-5331-4554)
- Carlo Ronsini (ORCID: https://orcid.org/0000-0002-9023-282X)
- Cinzia Di Pietro (ORCID: https://orcid.org/0000-0002-6036-4469)
- Elias Tsakos (ORCID: https://orcid.org/0000-0003-0972-2133)
- Marco Ragusa (ORCID: https://orcid.org/0000-0002-4282-920X)
- Anna Fazzio (ORCID: https://orcid.org/0009-0006-2045-8344)
- W. Sierka (ORCID: https://orcid.org/0009-0008-7511-6311)
- A Caponnetto (ORCID: https://orcid.org/0009-0009-0959-3133)
- Michele Stella (ORCID: https://orcid.org/0000-0002-3852-9933)
- Simone Palini (ORCID: https://orcid.org/0000-0002-2445-6518)
- Salvatore Longobardi (ORCID: https://orcid.org/0000-0003-4573-8087)
- Thomas D’Hooghe
- Maria Elena Vento
Institutions
- Merck KGaA, Darmstadt (Germany) (DE)
- University of Campania "Luigi Vanvitelli" (IT)
- Università degli Studi di Enna Kore (IT)
- University of Catania (IT)
- Ospedale Cervesi di Cattolica (IT)
- Wunschbaby Institut für Kinderwunsch (AT)
- Ospedale Cannizzaro (IT)
- Merck Serono S.p.A. (Italy) (IT)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1007/s10815-025-03457-x
- Citations
- 5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Università di Catania